From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9

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Scientist, Merck. Visiting Fellow. Akira RESEARCH Open Access The host-range, genomics and proteomics of Escherichia coli O157:H7 bacteriophage rV5 Andrew M Kropinski1,2, Tom Waddell3, Juncai Meng4, Kristyn Franklin1, Hans-Wolfgang Ackermann5, Rafiq Ahmed6, Rui Liang,1 Jun Lu,4 Zhijian Lu,1 Juncai Meng,4 Peter Orth,7 Oksana Palyha,6 Gopal Parthasarathy,4 Scott P. Salowe,5 Lansdale, PA 19446 Find on map >> Owner: JUNCAI MENG & YING GU MENG Total assessment value: $230,920 Sale date: 01/25/2010 Year property was built: 1987 Land use [5 Jul 2019 12:45] juncai meng . Description: Run mtr innodb.log_flush_order , mysql server core down: 2019-07-05T12:27:45.457029Z 0 [ERROR] [MY-013183 In situ click chemistry has been a powerful method for fragment-based drug design since its discovery in 2002. Recently, we demonstrated that the bacterial ribosome can template the azide–alkyne cycloaddition reaction to expedite the discovery of novel antibiotics. We now report this process can be performed in an antibiotic-resistant bacterial cell.

Juncai Xiang 翰仕人力资源有限公司 Senior Researcher. Jing'an Modular optimization of metal-organic frameworks (MOFs) was realized by incorporation of coordinatively unsaturated single atoms in a MOF matrix. The newly developed MOF can selectively capture and photoreduce CO₂ with high efficiency under visible-light irradiation. Kinetic target-guided synthesis (KTGS) is a powerful strategy in which the biological target selects its own inhibitors by assembling them from biocompatible reagents via an irreversible process. In this approach, the biological target accelerates the reaction between complementary building blocks by bringing them in close proximity and proper orientation. KTGS has found application on various As a label-free technology, mass spectrometry (MS) enables assays to be generated that monitor the conversion of substrates with native sequences to products without the requirement for substrate m Yonglin Peng 1 , Meng Yuan 1 , Juncai Xin 1 , Xinhua Liu 1 , Ju Wang 1 Affiliation 1 School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin 300070 China.

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18 Mar 2020 Polymorphisms Associated With Antidepressant Efficacy in Major Depressive Disorder. Juncai Xin, Meng Yuan, Yonglin Peng and Ju Wang*.

Publications 2. h-index 1. Citations 12. Highly Influential Citations 0.

6 Mar 2013 Andrew M Kropinski,; Tom Waddell,; Juncai Meng,; Kristyn Franklin,; Hans- Wolfgang Ackermann,

PMID: In situ click chemistry has been a powerful method for fragment-based drug design since its discovery in 2002. Recently, we demonstrated that the bacterial ribosome can template the azide–alkyne cycloaddition reaction to expedite the discovery of novel antibiotics. We now report this process can be performed in an antibiotic-resistant bacterial cell. The corresponding triazole products [5 Jul 2019 12:45] juncai meng . Description: Run mtr innodb.log_flush_order , mysql server core down: 2019-07-05T12:27:45.457029Z 0 [ERROR] [MY-013183 Juncai MA | Cited by 2,478 | of Chinese Academy of Sciences, Beijing (CAS) | Read 45 publications | Contact Juncai MA Synthesis and dynamic properties of kinetically inert lanthanide compounds: lanthanum(III) and europium(III) complexes of 1,4,7,10-tetrakis(2-hydroxyethyl)-1,4,7,10-tetraazacyclododecane [2] Zhen MENG, Juncai MA. Implementation strategy and design basis based on Web bioinformatics-analysis and data-delivering system. Application Research of Computers. 2008(25): 1302-1305.

Juncai Xin, Meng Yuan, Yonglin Peng and Ju Wang*. Juncai Ma's 8 research works with 27 citations and 807 reads, including: Evolutionary analysis and lineage designation C. Liu · Nan Zhou; Meng-Xuan Du; [. Andrew Kropinski; Tom Waddell · Juncai Meng; [] Roger Johnson. Sensitivity of reference strains of 12 common phage types of E. coli O157:H7 to lysis by Kinetic resolution by copper-catalyzed azide–alkyne cycloaddition. Jun-cai Meng , Valery V. Fokin, M.G. Finn · Details · Contributors · Fields of science Chen, Hong-Ming; Wang, Yin-Ye; Mao, Jian-Min; Cai, Meng-Shen; Jia, Zheng, Shangzhen; Meng, Juncai; Shen, Xuwei; Wang, Dinyun; Fu, Hua; Wang, Qin: 2019年10月22日 Huang,Brian Hubbard,Jennifer M Johnston,Michael Kavana,Jean-Marie Lisnock,Rui Liang,Jun Lu,Zhijian Lu,Juncai Meng,Peter Orth,Oksana 24 Mar 2011 Name: MA Juncai Dr. Juncai MA, who graduated from Biological Resource Department of Mie University, [2] Zhen MENG, Juncai MA. Juncai Meng · Principal Scientist at The Janssen Pharmaceutical Companies of Johnson & Johnson · About · Activity · Experience · Education · Publications · Groups. 5 Jun 2020 conceived the experiment and scientific discussions.
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Visiting Fellow. Akira Motoyama.
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As a label-free technology, mass spectrometry (MS) enables assays to be generated that monitor the conversion of substrates with native sequences to products without the requirement for substrate m

Liu, Xiangrong. Zhu, Bin. Cultural Goods and Archaeology Research河南省文物考古Ma ( Ma Juncai马 och arkeologi 湖北省文物考古研究所( Wang Ran王然, Meng Huaping孟华平) Jun Cai (8) Jian Cai (8) Wen Cai (7) Zhen Cai (7) Jun Cai (8) Jian Cai (8) Wen Cai (7) Zhen Cai (7) Meng Cai (2) Qiang Cai (2) Xue Cai (2) Guolin Cai (2) Julu (2); Jumin (2); Junan (3); Juncai (2); Junchang (2); Juncun (2); Junda (3) Menda (5); Mendang (2); Mende (11); Mendeng (2); Mendong (3); Meng (2) Fangfang Zhou.